今天有个不好的消息，林先生代母Holly的子宫评估顺利通过了，但是才得到的验血报告显示，她是间接抗球蛋白抗体阳性！ 不合适来代孕了，马上开除！因为将来孩子未出世有病理性溶血症就麻烦了！

但是林先生本身是乙肝病毒携带者，他代母一定要乙肝免疫的，非常不好找，所以拜托迪翊咨询的Tony与医生还是实验室主任探讨清楚此事， 而美国试管婴儿诊所的主任非常迅速了解释了问题，如下：

Dear Tony,
Checked with Monica, the Ab for Holly is anti-Rh-c, which is of high clinical significance (higher tan anti-RhE), with a >80% likelihood of the baby’s red cells exaggerating an immune response in the surrogate, and inducing HDN.
This would not be a good match.
我问过了护士MONICA，代母HOLLY的血型是anti-Rh-c（具有高的临床意义，比anti-RhE要高），在代孕中有大于80%的婴儿红细胞扩大免疫反应的可能性，包括新生儿溶血性疾病。
这可能不是一个好的代母匹配 哦！

I believe the antibody (initially) characterized for this surrogate was anti-RhE, which is clinically significant.  If it was detected earlier (but not with repeat testing), her titer may be waning, but the (initial) testing has established that the Ab is present.  If this surrogate conceived a child with the RhE antigen, there would be a likelihood of mild-severe hemolytic disease in her newborn.  Dr. XX  will make the final decision, but we typically would not want to chance HDN in a child from a third party cycle in which there is such great emotional and financial investment.
我相信代母的特征抗体（最初的）是 anti-RhE，具有高临床意义。如果更早发现（但不重复检查），她的效价可能会减弱，可是（最初的）测试显示血型是存在的。如果这个代母以为婴儿有RhE抗原，新生儿有中重度溶血性疾病的可能性。你的试管婴儿医生将会做最后的决定，可是我们通常不想冒来自这样重大的情感和经济投入下的引入第三方的试管婴儿周期下， 来冒着这种婴儿溶血性疾病的风险。

ERIC, MAgSc, PhD (Med), HCLD (ABB)
Director of Laboratories

 
联系电邮: usdytony@hotmail.com
DiYi Consulting迪翊咨询公司网址: http://www.diyiconsulting.com